Abstract
Amaç: Çocuklar ve ergenler, özellikle de kronik migreni olanlar, yaşam kalitesi ve okula devam
açısından daha kötü sonuçlara sahiptir. Migreni olmayan çocuklarla karşılaştırıldığında, anksiyete
ve depresyon gibi duygudurum bozuklukları yaşama olasılıkları daha yüksektir. Migren, anksiyete
ve depresyon gibi bozukluklarla ilişkisi üzerine en çok çalışma yapılan ağrı bozukluğudur. Ancak
epizodik migren ve kronik migrende bu komorbiditelerin sıklığını karşılaştıran yeterli çalışma
yoktur. Yöntem: Kronik migren tanısı olan 75 hasta ile epizodik migren tanısı olan 150 hasta
olmak üzere toplam 225 çocuk ve ergen baş ağrısı hastası çalışmaya dahil edildi. Veri seti Türkiye
baş ağrısı veri tabanı Mersin dalı kullanılarak oluşturuldu. Hastalar ağrı özellikleri ve eşlik eden
psikiyatrik komorbid hastalıklar açısından geriye dönük olarak değerlendirildi. Bulgular:
Beklendiği gibi ağrı şiddeti ve atak süresi kronik migreni olan hastalarda daha yüksekti (sırasıyla
p<0.001 ve p=0.027). Kronik migren grubunda depresyon oranları epizodik migren grubuna göre
daha yüksek iken, dikkat eksikliği hiperaktivite bozukluğu ise epizodik migren grubunda
istatistiksel olarak daha yüksekti (p=0.001). Anksiyete ve obsesif-kompulsif bozukluk açısından
ise gruplar arasında istatistiksel olarak anlamlı fark yoktu (p>0.05). Sonuç: Migreni olan çocuk ve
ergenlerde günlük yaşam aktiviteleri ve okul başarısı önemli ölçüde etkilenmektedir. Eşlik eden
psikiyatrik komorbiditeler de bu duruma katkıda bulunmaktadır. Bütünsel yaklaşım ve tedaviyi
optimize etmek için bu komorbiditelerin baş ağrısı bozukluklarıyla birlikte yönetilmesi önemlidir.
Supporting Institution
Hiçbir kurum ya da kuruluş tarafından desteklenmemiştir
Thanks
Yıllardır çocuk baş ağrısı polikliniğinin yürütülmesine katkı sağlayan doktor Gülen Güler Aksu’ya katkılarından dolayı teşekkür ederiz.
References
- Abu-Arefeh I, Russell G. Prevalence of headache and migraine in schoolchildren. BMJ 1994; 309: 765–9. doi:10.1136/bmj.309.6957.765
- Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia 2018;38 (1): 1-211. doi:10.1177/0333102417738202
- Wang SJ, Fuh JL, Lu SR, Juang KD. Chronic Daily headache in adolescents: prevalence, impact, and medication overuse. Neurology 2006;66: 193–7. doi:10.1212/01.wnl.0000183555.54305.fd
- Arruda MA, Guidetti V, Galli F, Albuquerque RC, Bigal ME. Frequent headaches in the preadolescent pediatric population: a population-based study Neurology 2010;74: 903–8. doi:10.1212/WNL.0b013e3181d561a2
- Kavuk I, Yavuz A, Cetindere U, Agelink MW, Diener HC. Epidemiology of chronic daily headache. Eur J Med Res 2003;8: 236–40. https://pubmed.ncbi.nlm.nih.gov/12911 872/ 6 Eylül 2023 tarihinde erişilmiştir.
- Natoli JL, Manack A, Dean B, and et al. Global prevalence of chronic migraine: a systematic review. Cephalalgia 2010;30(5):599–609 doi:10.1111/j.1468-2982.2009.01941.x
- Tietjen GE, Herial NA, Hardgrove J, Utley C, White L. Migraine comorbidity constellations. Headache 2007;47:857– 865 doi:10.1111/j.1526-4610.2007.00814.x
- Buse DC, Manack A, Serrano D, Turkel C, Lipton RB. Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. J Neurol Neurosurg Psychiatry 2010;81:428–432 doi:10.1136/jnnp.2009.192492
- Louter MA, Pijpers JA, Wardenaar KJ, and et al. Symptom dimensions of affective disorders in migraine patients. J Psychosom Res 2015;79(5):458–63. doi:10.1016/j.jpsychores.2015.09.014
- Pavone P, Rizzo R, Conti I, and et al. Primary headaches in children: Clinical findings on the association with other conditions. Int J Immunopath Pharmacol. 2012;25(4):1083-1091. doi:10.1177/039463201202500425
- Scher AI, Bigal ME, Lipton RB. Comorbidity of migraine. Curr Opin Neurol 2005;18:305–310. doi:10.1097/01.wco.0000169750.52406.a2
- Breslau N, Davis GC, Andreski P. Migraine, psychiatric disorders, and suicide attempts: en epidemiological study of young adults. Psychiatry Res 1991;37:11–23 doi:10.1016/0165-1781(91)90102-u
- Turkish headache database. website: http://www.epikriz.com/index.aspx. 30 Ağustos 2023 tarihinde erişilmiştir.
- Antonaci, F, Nappi G, Galli F, Manzoni GC, Calabresi P, Costa A. Migraine and psychiatric comorbiditiy: a review of clinical findings. J Headache Pain 2011;12(2):115-125. doi:10.1007/s10194-010-0282-4
- Salem H, Vivas D, Cao, F, Kazımi, IF, Teixeira AL, Zeni CP. ADHD is associated with migraine: a systematic review and meta-analysis. Eur Child Adolesc Psychiatry 2018;27(3):267-277. doi:10.1007/s00787-017-1045-4
- Kutuk MO, Tufan AE, Güler G, and et al. Migraine and associated comorbidities are three times more frequent in children with ADHD and their mothers. Brain Dev 2018;40(10):857-864. doi:10.1016/j.braindev.2018.06.001
- Seshia SS. Chronic daily headache in children and adolescents. Curr Pain Headache Rep 2012;16(1):60-72. doi:10.1007/s11916-011-0228-9
- Babicka-Wirkus A, Kozlowski P, Wirkus L, Stasiak K. Internalizing and externalizing disorder levels among adolescents: Data from Poland. Int J Environ Res Public Health 2023;20(3):2752. doi:10.3390/ijerph20032752
- Ercan, ES, Polanczyk, G, Ardıc, UA, and et al. The prevalence of childhood psychopathology in Turkey: a cross-sectional multicenter nationwide study (EPICPAT-T). Nor J Psychiatry 2019;73 (2):132-140. doi:10.1080/08039488.2019.1574892
- Loth AK, Drabick DAG, Leibenluft E, Hulvershorn LA. Do childhood externalizing disorders predict adult depression? A meta-analysis. J Abnorm Child Psychol 2014;42(7):1103-1113. doi:10.1007/s10802-014-9867-8
- Fearon P, Hotopf M. Relation between headache in childhood and physical and psychiatric symptoms in adulthood: national birth cohort study. BMJ 2001;322(7295):1145. doi:10.1136/bmj.322.7295.1145
Abstract
Aim: Children and adolescents, particularly those with chronic migraine, have worse outcomes
regarding quality of life and school attendance. Compared with children without migraine, they
are more likely to have anxiety and mood disorders, such as depression. Migraine is the most
studied pain disorder in terms of being associated with disorders such as anxiety and depression.
However, there are not enough studies comparing the frequency of these comorbidities in
episodic migraine and chronic migraine. Method: A total of 225 pediatric headache patients, 75
with chronic migraine and 150 with episodic migraine were included. The data set was composed
using the Turkish headache database, Mersin Branch. The patients were evaluated in terms of pain
characteristics and accompanying psychiatric comorbidities retrospectively. Results: As
expected, pain intensity and duration of attacks were higher in patients with chronic migraine
(p<0.001 and p=0.027, respectively). While depression rates were higher in the chronic migraine
group than in the episodic migraine group, attention-deficit hyperactivity disorder was
statistically higher in the episodic migraine group (p=0.001). When compared in terms of anxiety
and obsessive-compulsive disorder, there was no statistically significant difference (p>0.05).
Conclusion: Daily living activities and school success are significantly affected in the pediatric
migraine. Concomitant psychiatric comorbidities also contribute to this condition. It is important
to manage these comorbidities together with headache disorders in order to optimize the holistic
approach and treatment.
References
- Abu-Arefeh I, Russell G. Prevalence of headache and migraine in schoolchildren. BMJ 1994; 309: 765–9. doi:10.1136/bmj.309.6957.765
- Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia 2018;38 (1): 1-211. doi:10.1177/0333102417738202
- Wang SJ, Fuh JL, Lu SR, Juang KD. Chronic Daily headache in adolescents: prevalence, impact, and medication overuse. Neurology 2006;66: 193–7. doi:10.1212/01.wnl.0000183555.54305.fd
- Arruda MA, Guidetti V, Galli F, Albuquerque RC, Bigal ME. Frequent headaches in the preadolescent pediatric population: a population-based study Neurology 2010;74: 903–8. doi:10.1212/WNL.0b013e3181d561a2
- Kavuk I, Yavuz A, Cetindere U, Agelink MW, Diener HC. Epidemiology of chronic daily headache. Eur J Med Res 2003;8: 236–40. https://pubmed.ncbi.nlm.nih.gov/12911 872/ 6 Eylül 2023 tarihinde erişilmiştir.
- Natoli JL, Manack A, Dean B, and et al. Global prevalence of chronic migraine: a systematic review. Cephalalgia 2010;30(5):599–609 doi:10.1111/j.1468-2982.2009.01941.x
- Tietjen GE, Herial NA, Hardgrove J, Utley C, White L. Migraine comorbidity constellations. Headache 2007;47:857– 865 doi:10.1111/j.1526-4610.2007.00814.x
- Buse DC, Manack A, Serrano D, Turkel C, Lipton RB. Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. J Neurol Neurosurg Psychiatry 2010;81:428–432 doi:10.1136/jnnp.2009.192492
- Louter MA, Pijpers JA, Wardenaar KJ, and et al. Symptom dimensions of affective disorders in migraine patients. J Psychosom Res 2015;79(5):458–63. doi:10.1016/j.jpsychores.2015.09.014
- Pavone P, Rizzo R, Conti I, and et al. Primary headaches in children: Clinical findings on the association with other conditions. Int J Immunopath Pharmacol. 2012;25(4):1083-1091. doi:10.1177/039463201202500425
- Scher AI, Bigal ME, Lipton RB. Comorbidity of migraine. Curr Opin Neurol 2005;18:305–310. doi:10.1097/01.wco.0000169750.52406.a2
- Breslau N, Davis GC, Andreski P. Migraine, psychiatric disorders, and suicide attempts: en epidemiological study of young adults. Psychiatry Res 1991;37:11–23 doi:10.1016/0165-1781(91)90102-u
- Turkish headache database. website: http://www.epikriz.com/index.aspx. 30 Ağustos 2023 tarihinde erişilmiştir.
- Antonaci, F, Nappi G, Galli F, Manzoni GC, Calabresi P, Costa A. Migraine and psychiatric comorbiditiy: a review of clinical findings. J Headache Pain 2011;12(2):115-125. doi:10.1007/s10194-010-0282-4
- Salem H, Vivas D, Cao, F, Kazımi, IF, Teixeira AL, Zeni CP. ADHD is associated with migraine: a systematic review and meta-analysis. Eur Child Adolesc Psychiatry 2018;27(3):267-277. doi:10.1007/s00787-017-1045-4
- Kutuk MO, Tufan AE, Güler G, and et al. Migraine and associated comorbidities are three times more frequent in children with ADHD and their mothers. Brain Dev 2018;40(10):857-864. doi:10.1016/j.braindev.2018.06.001
- Seshia SS. Chronic daily headache in children and adolescents. Curr Pain Headache Rep 2012;16(1):60-72. doi:10.1007/s11916-011-0228-9
- Babicka-Wirkus A, Kozlowski P, Wirkus L, Stasiak K. Internalizing and externalizing disorder levels among adolescents: Data from Poland. Int J Environ Res Public Health 2023;20(3):2752. doi:10.3390/ijerph20032752
- Ercan, ES, Polanczyk, G, Ardıc, UA, and et al. The prevalence of childhood psychopathology in Turkey: a cross-sectional multicenter nationwide study (EPICPAT-T). Nor J Psychiatry 2019;73 (2):132-140. doi:10.1080/08039488.2019.1574892
- Loth AK, Drabick DAG, Leibenluft E, Hulvershorn LA. Do childhood externalizing disorders predict adult depression? A meta-analysis. J Abnorm Child Psychol 2014;42(7):1103-1113. doi:10.1007/s10802-014-9867-8
- Fearon P, Hotopf M. Relation between headache in childhood and physical and psychiatric symptoms in adulthood: national birth cohort study. BMJ 2001;322(7295):1145. doi:10.1136/bmj.322.7295.1145
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Services and Systems (Other) |
| Journal Section | Articles |
| Authors | |
| Early Pub Date | December 5, 2023 |
| Publication Date | December 18, 2023 |
| Submission Date | September 6, 2023 |
| Acceptance Date | September 20, 2023 |
| Published in Issue | Year 2023 Volume: 16 Issue: 3 |
Cite
MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
Publishing in three issues per year (April - August - December), it is a multisectoral refereed scientific journal. In addition to research articles, scientific articles such as reviews, case reports and letters to the editor are published in the journal. Our journal, which has been published via e-mail since its inception, has been published both online and in print. Following the Participation Agreement signed with TÜBİTAK-ULAKBİM Dergi Park in April 2015, it has started to accept and evaluate online publications.
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